Cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) are two vital and active components of medical cannabis (THC). THC, one of the active components in cannabis, activates the CB1 and CB2 cannabinoid receptors. Injured tissues produce 2-arachidonoyl-sn-glycerol (2-AG), anandamide, and endocannabinoids, which are known to reduce sensitization and inflammation by activating cannabinoid (CB) receptors.
CBD and THC both help to alleviate pain at the injured site. THCs have anti-inflammatory qualities because they activate CB2 receptors on immune cells, which reduces the body’s pain-inducing response to damage. CBD, on the other hand, decreases inflammation by inhibiting inflammatory mediators and switching pro-inflammatory macrophage repair cells to anti-inflammatory ones.
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